Publications

The use of hematopoietic cell transplantation (HCT) for treating malignant conditions in children has increased over the past five decades, leading to a growing population of long-term survivors.This population of childhood HCT survivors faces increased risks of adverse medical effects due to cancer treatments, including adverse cardiovascular disease (CVD) risk factors such as metabolic syndrome, insulin resistance. but the impact of exposure to HCT preparative conditioning regimen has not been...

The aim of this study was to determine the effect of circulating endothelial cell-derived microvesicles (EMVs) isolated from e-cigarette users on human cerebral microvascular endothelial cells (hCMECs) nitric oxide (NO) and endothelin (ET)-1 production and tissue-type plasminogen activator (t-PA) release. Circulating EMVs (CD144-PE) were isolated (flow cytometry) from 27 young adults (19-25 yr): 10 nonsmokers (6 M/4 F), 10 e-cigarette users (6 M/4 F), and 7 tobacco cigarette smokers (4 M/3 F)....

Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in trained runners. Here we compared the association between circulating FAHFA baseline concentrations and body composition, determined by dual x-ray absorptiometry, in female runners who were lean (BMI < 25 kg/m², n = 6), to those who were overweight (BMI ≥ 25 kg/m², n = 7). We also compared circulating FAHFAs in lean male...

Background: This study examined the associations between BMI trajectories and emerging cardiometabolic risk (CMR) in children living in low-income and racially and ethnically diverse households in the United States. Methods: Data were drawn from NET-Works randomized intervention trial and NET-Works 2 prospective follow-up study (N = 338). BMI was measured across 6 follow-up visits and biomarkers of cardiometabolic risk (CMR) at the sixth visit. Group-based trajectory modeling identified child...

CONCLUSIONS: Adiposity measures all decreased after RYGB but poorly predicted change in cardiometabolic risk. Despite significant reductions at 1 year, a steady regain was observed out to 5 years, with values still well below baseline. Further research should consider control group comparison and extended follow-up.

CONCLUSIONS: The DXA can be used to create four-compartment model for estimating total and regional fat mass, fat-free mass, and percent fat. Therefore, these results allow for a convenient regional four-compartment model with DXA derived regional volume.

The purpose of the present study was to examine the muscle-to-bone ratio (MBR) in National Football League (NFL) players. Three hundred and forty-six NFL players had their total body lean, fat and bone masses determined using dual X-ray absorptiometry and were compared to 228 age-matched, healthy male controls. Compared to the control group, NFL players had a significantly lower percent total body fat (17.90±6.92 vs. 22.93±8.96%, p=0.053), but significantly greater total fat mass (19.76±11.29...

This study explored body composition in female NCAA Division I rowers compared to controls; and the effect of season, boat category, and oar side on body composition. This retrospective analysis of 91 rowers, and 173 age, sex, and BMI-matched controls examined total and regional fat mass (FM), lean mass (LM), bone mineral content (BMC), bone mineral density (BMD), percent body fat (%BF), and visceral adipose tissue (VAT) measured using dual X-ray absorptiometry. Two-sample t-testing was used to...

CONCLUSIONS: Children with obesity had a higher MBR and SBR compared to their normal weight peers. In addition, there were significant associations between SBR, higher levels of insulin, atherogenic lipoproteins, and increased systolic blood pressure. Thus, SBR may be useful as a marker for increased cardiometabolic disease risk, though more research in this area is warranted.

CONCLUSIONS: The DXA may be used as valid method for estimating total and regional body volume. Thus, these results expand the DXA's capabilities and potentially allow for a convenient regional four-compartment model with DXA-derived regional volume.

Background Microparticles and endothelial microparticles (EMPs) are implicated in accelerating cardiovascular disease (CVD); however, data in pediatrics are limited. We examined the relationship of microparticles and EMPs with adiposity and subclinical CVD risk measures in a pediatric population to determine their potential as biomarkers of CVD risk. Methods and Results A cross-sectional study of youth (n=280; ages 8-20 years) with a range of body mass index categories was used. Microparticles,...

Czeck, MA, Roelofs, EJ, Evanoff, NG, and Dengel, DR. No Changes in body composition in NCAA Division I Collegiate Football Players due to COVID-19 restrictions. J Strength Cond Res 36(6): 1749-1752, 2022-The purpose of this study was to explore the impact of coronavirus disease 2019 (COVID-19) restrictions on body composition, assessed by dual x-ray absorptiometry (DXA), between the 2020 postseason (pre-COVID-19 restrictions) and the 2021 postseason (post-COVID-19 restrictions) in collegiate...

CONCLUSIONS: Although not achieving statistical significance, exenatide XR, compared with placebo, may partly mitigate the propensity toward BMI rebound in adolescents who achieved initial weight loss with dietary intervention.

No abstract

Czeck, MA, Roelofs, EJ, Dietz, C, Bosch, TA, and Dengel, DR. Body composition and on-ice skate times for NCAA Division I collegiate male and female ice hockey athletes. J Strength Cond Res 36(1): 187-192, 2022-This study's purpose was to explore positional differences for an on-ice timed skate test and its relationship to body composition. Male (n = 15) and female (n = 18) collegiate hockey players participated in this study (total n = 33). Each player was categorized by position of forward or...

Childhood cancer survivors who receive a hematopoietic cell transplantation (HCT) are at increased risk for follicle-stimulating hormone (FSH) abnormalities, which may have a substantial negative impact on vascular function. The purpose of this study was to examine the association of vascular function with FSH in HCT recipients, non-HCT recipients and healthy controls. The study included childhood cancer survivors who were HCT recipients (n=24) and non-HCT recipients (n=308), and a control group...

CONCLUSIONS: This study's results show that HCT recipients have significant reductions in BMD, worse body composition, and abnormal FSH levels compared to non-HCT recipients and healthy controls.

Eighty-three male and female (49/34) athletes underwent determination of total fat mass (FM), lean mass (LM), bone mineral density (BMD) and visceral adipose tissue (VAT) by dual X-ray absorptiometry during the pre-season, in-season and off-season. Athletes were classified by position of Goalie (G; M/F=7/6), Forward (F; M/F=26/18), or Defenseman (D; M/F=16/10). In males, all positions were similar in weight, FM, LM, BMD and VAT. In females, F weighed less than D and G. FM and VAT was lower in F...

Persons with spinal cord injury (SCI) have increased adiposity that may predispose to cardiovascular disease compared to those who are able-bodied (AB). The purpose of this study was to determine the relationships between dual energy X-ray absorptiometry (DXA)-derived visceral adipose tissue (VAT) and biomarkers of lipid metabolism and insulin resistance in persons with chronic SCI. A prospective observational study in participants with chronic SCI and age- and gender-matched AB controls. The...

Background Circulating endothelial cells (CECs) reflect early changes in endothelial health; however, the degree to which CEC number and activation is related to adiposity and cardiovascular risk factors in youth is not well described. Methods and Results Youth in this study (N=271; aged 8-20 years) were classified into normal weight (body mass index [BMI] percentage <85th; n=114), obesity (BMI percentage ≥95th to <120% of the 95th; n=63), and severe obesity (BMI percentage ≥120% of the 95th;...